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Cat. No.: HY-178824

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EGFR-IN-180

EGFR-IN-180 (Compound L15) is an EGFR inhibitor. EGFR-IN-180 shows inhibitory activity against EFGR and EGFR harboring the L858R/T790M/C797S triple drug-resistant mutation, with IC₅₀ values of 80.96 nM and 16.43 nM, reapectively. EGFR-IN-180 can be used for the study of non-small cell lung cancer (NSCLC).

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CAS No.: 1454651-67-2
Formule: C₃₀H₃₈ClN₇O₃
Masse moléculaire:580.12

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

EGFR-IN-180 Chemical Structure

CAS No.: 1454651-67-2

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Description

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Chemical Information

CAS No. 1454651-67-2
Masse moléculaire 580.12
Formule C₃₀H₃₈ClN₇O₃
SMILES

O=C(C1=C(NC2=NC(NC3=CC=C4C(CCCC(C4)N5CCN(CC5)CCO)=C3OC)=NC=C2Cl)C=CC=C1)NC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sun Z, et al. Accelerating Scaffold Hopping in Fourth-Generation Epidermal Growth Factor Receptor Inhibitors via Multilevel Virtual Screening. ACS Med Chem Lett. 2025 Sep 30;16(10):1927-1934. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR-IN-180

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EGFR-IN-180 Related Classifications

HY-178824 Related Classifications

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