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Cat. No.: HY-162461

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HIV-1 inhibitor-66

HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC₅₀ of 40 nM.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₅BrClF₃N₄O₃
Molecular Weight:555.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HIV-1 inhibitor-66 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	118 μM Compound: 10n	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability by MTT assay	[PMID: 38613773]

In Vitro

HIV-1 inhibitor-66 (compound 10n) inhibits wild-type (WT) HIV-1 (IIIB) and NNRTIs-resistant strains, with EC₅₀ values of 0.009 μM, 0.011 μM, 0.013 μM, 0.018 μM, 0.703 μM, 0.013 μM,17.7 μM, and 0.059 μM against HIV-1 IIIB, L100I, K103N, Y181C, Y188L, E138 K, F227L/V106A, and RES056 (K103N/Y181C), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HIV-1 inhibitor-66 (compound 10n) demonstrates excellent pharmacokinetic profile (T_1/2=5.09 h, F=108.96%) in rats. HIV-1 inhibitor-66 is verified to have no in vivo acute or subacute toxicity (LD50>2000 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 555.73
Formula C₂₂H₁₅BrClF₃N₄O₃
SMILES

O=C1N(C=CC(C(F)(F)F)=C1OC2=CC(C3=CC=C(C=C3)Br)=CC(Cl)=C2)CC4=NNC(N4C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yanying Sun, et al. Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. J Med Chem. 2024 Apr 25;67(8):6570-6584. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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HIV-1 inhibitor-66

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HIV-1 inhibitor-66 Related Classifications

HY-162461 Related Classifications