Trimethylacetaldehyde
Based on 1 Customer Validation
Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism.
For research use only. We do not sell to patients.
- CAS No.: 630-19-3
- Formula: C5H10O
- Molecular Weight:86.13
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Trimethylacetaldehyde (0.5-10 mM) is oxidized by purified Drosophila melanogaster AdhS in a dismutation reaction at pH 9.5 and 23.5 °C, with a Km of 2.4 mM[1].
Trimethylacetaldehyde (100 mM) competitively inhibits purified betaine aldehyde dehydrogenase from Escherichia coli MC4100 (pFF423), with an apparent inhibition constant of 4.5 mM, and reduces the enzyme activity to 11% of that in the control group at a concentration of 100 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 630-19-3
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Appearance Liquid (Density: 0.7821 g/cm3)
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Molecular Weight 86.13
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Formula C5H10O
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Color Colorless to light yellow
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SMILES
O=CC(C)(C)C
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Synonyms
Pivalic aldehyde; Pivalaldehyde
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
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Handling Instructions (2659 KB)
References
[1]. Winberg JO, et al. Drosophila melanogaster alcohol dehydrogenase: mechanism of aldehyde oxidation and dismutation. The Biochemical journal. 1998 Feb 01;329 ( Pt 3)(Pt 3):561-70. [Content Brief]
[2]. Falkenberg P, et al. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Biochimica et biophysica acta. 1990 Jun 20;1034(3):253-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trimethylacetaldehyde Related Classifications
HY-Y1668 Related Classifications
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