2. Cytoskeleton
  3. Myosin
  4. Myosin-IN-4

Myosin-IN-4 (Compound 3), a pyridine-2,4-dione derivative, is a myocardial myosin inhibitor. Myosin-IN-4 has a strong inhibitory activity against cardiac myosin ATPase with an IC50 value of 0.73 μM. Myosin-IN-4 exert a negative inotropic effect by inhibiting myocardial contraction. Myosin-IN-4 can be used for the research on cardiovascular diseases related to cardiac myosin.

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Myosin-IN-4

Myosin-IN-4 Chemical Structure

CAS No. : 2823425-92-7

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Myosin-IN-4 Related Antibodies

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Description

Myosin-IN-4 (Compound 3), a pyridine-2,4-dione derivative, is a myocardial myosin inhibitor. Myosin-IN-4 has a strong inhibitory activity against cardiac myosin ATPase with an IC50 value of 0.73 μM. Myosin-IN-4 exert a negative inotropic effect by inhibiting myocardial contraction. Myosin-IN-4 can be used for the research on cardiovascular diseases related to cardiac myosin[1].

Parmacokinetics
Species Dose Route CL C0 Vd T1/2 AUC
Rat[1] 0.2 mg/kg i.v. 8.11 mL/min/kg 0.773 μM 1.6 L/kg 2.31 h 1.331 μM·h
Rat[1] 1 mg/kg i.g. / / / / /
Molecular Weight

284.35

Formula

C17H20N2O2
CAS No.
SMILES

O=C(NC(N[C@H](C1=CC=CC=C1)C)=CC2=O)C32CCCC3
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Myosin-IN-4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myosin-IN-42823425-92-7MyosinInhibitorinhibitorinhibit

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