Trypanothione synthetase-IN-5
Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM.
For research use only. We do not sell to patients.
- CAS No.: 3037664-05-1
- Formula: C35H39F2IN4O3
- Molecular Weight:728.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage | CC50 |
29.9 μM
Compound: 9
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Cytotoxicity against BALB/c mouse peritoneal macrophages assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against BALB/c mouse peritoneal macrophages assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 38164929] |
| THP-1 | CC50 |
38.4 μM
Compound: 9
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Cytotoxicity against PMA-differentiated human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against PMA-differentiated human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 38164929] |
Chemical Information
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CAS No. 3037664-05-1
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Molecular Weight 728.61
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Formula C35H39F2IN4O3
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SMILES
O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)