1. Epigenetics
  2. Histone Demethylase
  3. JMJD7-IN-1

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.

For research use only. We do not sell to patients.

JMJD7-IN-1 Chemical Structure

JMJD7-IN-1 Chemical Structure

CAS No. : 311316-96-8

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10 mM * 1 mL in DMSO
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Description

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7[1].

IC50 & Target

IC50: 6.62 μM (JMJD7)[1]

In Vitro

JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM[1].
JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM[1].
JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.15

Formula

C16H8Cl2N2O4

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1)C3=CC=C(Cl)C=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (22.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7537 mL 13.7684 mL 27.5368 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7537 mL 13.7684 mL 27.5368 mL 68.8421 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL 13.7684 mL
10 mM 0.2754 mL 1.3768 mL 2.7537 mL 6.8842 mL
15 mM 0.1836 mL 0.9179 mL 1.8358 mL 4.5895 mL
20 mM 0.1377 mL 0.6884 mL 1.3768 mL 3.4421 mL
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JMJD7-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JMJD7-IN-1
Cat. No.:
HY-132198
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