JMJD7-IN-1
Based on 1 publication(s) in Google Scholar
JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
For research use only. We do not sell to patients.
- Purity: 98.57%
- CAS No.: 311316-96-8
- Formula: C16H8Cl2N2O4
- Molecular Weight:363.15
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) JMJD7-IN-1
More
Biological Activity
IC50: 6.62 μM (JMJD7)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BJ | IC50 |
>100 μM
Compound: 3
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Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 34048880] |
| HeLa | IC50 |
16.14 μM
Compound: 3
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Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34048880] |
| Jurkat | IC50 |
15.03 μM
Compound: 3
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Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 34048880] |
| SH-SY5Y | IC50 |
>100 μM
Compound: 3
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Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 34048880] |
| SK-BR-3 | IC50 |
13.26 μM
Compound: 3
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Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34048880] |
| T47D | IC50 |
9.4 μM
Compound: 3
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Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34048880] |
JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM[1].
JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM[1].
JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 311316-96-8
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Appearance Solid
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Molecular Weight 363.15
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Formula C16H8Cl2N2O4
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Color White to light yellow
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SMILES
O=C(OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1)C3=CC=C(Cl)C=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Clin Exp Med
Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]2025 Nov 25;26(1):33. PMID: 41286164
Solvent & Solubility
DMSO : 8.33 mg/mL (22.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7537 mL | 13.7684 mL | 27.5368 mL | 68.8421 mL |
| 5 mM | 0.5507 mL | 2.7537 mL | 5.5074 mL | 13.7684 mL | |
| 10 mM | 0.2754 mL | 1.3768 mL | 2.7537 mL | 6.8842 mL | |
| 15 mM | 0.1836 mL | 0.9179 mL | 1.8358 mL | 4.5895 mL | |
| 20 mM | 0.1377 mL | 0.6884 mL | 1.3768 mL | 3.4421 mL |
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