country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-120711

Copy Link Print Information

BRD0476

(Synonyms: ML187)

BRD0476 is an inhibitor of pancreatic β-cell apoptosis with an EC₅₀ value of 0.78 μM and a maximal inhibitory activity of 99%. BRD0476 can be used in diabetes-related research.

For research use only. We do not sell to patients.

CAS No.: 1314958-91-2
Formula: C₃₅H₃₈N₄O₈S
Molecular Weight:674.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BRD0476 Chemical Structure

CAS No.: 1314958-91-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BRD0476 is an inhibitor of pancreatic β-cell apoptosis with an EC₅₀ value of 0.78 μM and a maximal inhibitory activity of 99%. BRD0476 can be used in diabetes-related research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
INS-1E	EC₅₀	0.78 μM Compound: 13, BRD0476	Inhibition of IL-1beta, IFN-gamma and TNF-alpha-induced apoptosis of rat INS-1E cells assessed as restoring cell viability after 48 hrs by luciferase based CellTiter-Glo assay Inhibition of IL-1beta, IFN-gamma and TNF-alpha-induced apoptosis of rat INS-1E cells assessed as restoring cell viability after 48 hrs by luciferase based CellTiter-Glo assay	[PMID: 21927648]
INS-1E	IC₅₀	1.66 μM Compound: 1, BRD0476	Cytoprotective activity in rat INS-1E cells assessed as suppression of cytokine-induced caspase-3/7 activation after 48 hrs by luminescence assay Cytoprotective activity in rat INS-1E cells assessed as suppression of cytokine-induced caspase-3/7 activation after 48 hrs by luminescence assay	[PMID: 23617753]

In Vitro

BRD0476 reduces caspase-3 activity in a dose-dependent manner in the presence of cytokines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1314958-91-2
Molecular Weight 674.76
Formula C₃₅H₃₈N₄O₈S
SMILES

O=C(NC1=C(C2=CC=C1)O[C@H]([C@@H](CN(C2=O)[C@H](CO)C)C)CN(C)S(=O)(C3=CC=C4OCCOC4=C3)=O)NC5=C6C=CC=CC6=CC=C5
Synonyms

ML187
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chou DH, et al. Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote