HDAC6-IN-15
HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C25H28FFeN3O2
- Molecular Weight:477.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 38.2 nM (IC50) |
HDAC6-IN-15 (Compound II-5) has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM[1].
HDAC6-IN-15 (50 μL; 48 h) has antitumor activity against 22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells with IC50 value of 8.90 μM, 11.90 μM, 7.83 μM, 4.80 μM and 16.51 μM, respectively[1].
HDAC6-IN-15 (100, 200, 400, 800 nM; 24 h) dose-dependently induces accumulation of acetylated a-tubulin[1].
HDAC6-IN-15 (5, 10 μM; 24 h) can induce cellular apoptosis[1].
HDAC6-IN-15 (4 mg/mL; 48 h) demonstrates an optimal profile on human plasma stability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells
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Concentration:50 μL
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Incubation Time:48 h
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Result:Showed moderate anti-proliferative activities in all the cancer cell lines.
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Cell Line:JEKO-1 cells; 4T1 cells
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Concentration:100, 200, 400, 800 nM; 5, 10 μM
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Incubation Time:24 h
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Result:Significantly increase the levels of acetylated α-tubulin in a concentration dependent manner.
Slightly increased the levels of histone H3 and H4 acetylation.
Significantly increased the ratio of acetylated α-tubulin at the concentration of 800 nM.
Dramatically increased the levels of cleavage of PARP and caspase-3 in cells dose-dependently.
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Cell Line:4T1 cells
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Concentration:5, 10 μM
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Incubation Time:24 h
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Result:Triggered apoptosis in 4T1 cells in a dose-dependent manner, in particularly undergoing early stage apoptosis upon 18 h treatment.
Chemical Information
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Molecular Weight 477.35
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Formula C25H28FFeN3O2
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SMILES
[][Fe][].FC(C=C(C(NO)=O)C=C1)=C1CN(CC2)CCN2C(CCc3cccc3)c4cccc4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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