HCN2-IN-6
HCN2-IN-6 is a HCN2 ion channel inhibitor with an IC50 of 7 nM. HCN2-IN-6 shows weak inhibitory activity for HCN4. HCN2-IN-6 can be used for the research of inflammatory disease and neurological disorders.
For research use only. We do not sell to patients.
- CAS No.: 3080808-95-0
- Formula: C22H18N6O4S
- Molecular Weight:462.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HCN2 7 nM (IC50) |
HCN1 568 nM (IC50) |
HCN4 2770 nM (IC50) |
HCN2 modulator-2 (Compound 31) potently inhibits human HCN2 channels with an IC50 of 7 nM, inhibits human HCN4 channels with an IC50 of 568 nM, and does not significantly inhibit human HCN1 channels (IC50 = 2770 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3080808-95-0
-
Molecular Weight 462.48
-
Formula C22H18N6O4S
-
SMILES
N#CC1=CC(C2=CN=C3C(C(NC(C4=CC=NS4)=O)=NN3CC(C)OC)=C2)=CC5=C1OCO5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz