EGFR-IN-90
EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor. EGFR-IN-90 shows inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and inhibits the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM. EGFR-IN-90 and inhibits tumor growth in the H1975-TM xenograft tumor model.
For research use only. We do not sell to patients.
- CAS No.: 3008611-00-2
- Formula: C32H36FN7O2S2
- Molecular Weight:633.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
5.1 nM(EGFR)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
1.4 μM
Compound: C34
|
Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
|
[PMID: 37885208] |
| NCI-H1975 | IC50 |
0.21 μM
Compound: C34
|
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
|
[PMID: 37885208] |
| PC-9 | IC50 |
0.005 μM
Compound: C34
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Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
|
[PMID: 37885208] |
| PC-9 | IC50 |
0.03 μM
Compound: C34
|
Antiproliferative activity against human PC-9 cells harbouring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
Antiproliferative activity against human PC-9 cells harbouring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
|
[PMID: 37885208] |
Chemical Information
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CAS No. 3008611-00-2
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Molecular Weight 633.80
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Formula C32H36FN7O2S2
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SMILES
FC1=CC=C(C=C1)C2=C(SC(C3CCN(CC3)S(=O)(CC)=O)=N2)C4=CC=NC(NC5=CC=C6N(C=CC6=C5)CCN(C)C)=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)