3008611-00-2
3008611-00-2
Chemical Structure
EGFR-IN-90
- CAS No.: 3008611-00-2
- Formula:C32H36FN7O2S2
- Molecular Weight:633.80
InChIKey: URSAVMMLTMTCOJ-UHFFFAOYSA-N
SMILES: FC1=CC=C(C=C1)C2=C(SC(C3CCN(CC3)S(=O)(CC)=O)=N2)C4=CC=NC(NC5=CC=C6N(C=CC6=C5)CCN(C)C)=N4
Biological Activity: EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor. EGFR-IN-90 shows inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and inhibits the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM. EGFR-IN-90 and inhibits tumor growth in the H1975-TM xenograft tumor model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
EGFR-IN-90 | EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor. EGFR-IN-90 shows inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and inhibits the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM. EGFR-IN-90 and inhibits tumor growth in the H1975-TM xenograft tumor model. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
