Makaluvamine A
Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 146555-78-4
- Formula: C11H11N3O
- Molecular Weight:201.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
>0.17 μM
Compound: Makaluvamine A
|
Cytotoxicity against human HCT116 cells
Cytotoxicity against human HCT116 cells
|
[PMID: 22686608] |
| NIH3T3 | IC50 |
5 μM
Compound: 9
|
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
|
[PMID: 12027767] |
| P388 | ED50 |
0.4 μg/mL
Compound: 2
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 8946754] |
| XRS6 | IC50 |
0.08 μM
Compound: Makaluvamine A
|
Cytotoxicity against Chinese hamster Xrs-6 cells
Cytotoxicity against Chinese hamster Xrs-6 cells
|
[PMID: 22686608] |
Chemical Information
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CAS No. 146555-78-4
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Molecular Weight 201.22
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Formula C11H11N3O
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SMILES
O=C1C2=C3C(CCN=C3C=C1N)=CN2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)