Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K

  • Org Lett. 2023 Mar 24;25(11):1868-1871. doi: 10.1021/acs.orglett.3c00350.
Jason An  1 ,  Richard K Jackson 3rd  1 ,  Joseph P Tuccinardi  1 ,  John L Wood  1
Affiliations
  • 1. Department of Chemistry and Biochemistry, Baylor University, One Bear Place 97348, Waco, Texas 76798, United States.
PMID: 36913953 DOI: 10.1021/acs.orglett.3c00350
Abstract

Herein, an efficient, scalable, and concise approach to an advanced pyrroloiminoquinone synthetic intermediate (6b) by way of a Larock indole synthesis is reported. The synthetic utility of this intermediate is demonstrated by its ready conversion to makaluvamines A (1) and K (4).

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