2. Cell Cycle/DNA Damage Membrane Transporter/Ion Channel
  3. Eukaryotic Initiation Factor (eIF) Potassium Channel
  4. eIF2B activator-1

eIF2B activator-1 (Compound 7a) is a eIF2B activator with a pEC50 value of 7.3. eIF2B activator-1 exhibits significant hERG inhibitory activity, with a pIC50 value of 5.7. eIF2B activator-1 can be used in research related to Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

eIF2B activator-1

eIF2B activator-1 Chemical Structure

CAS No. : 3118633-46-5

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eIF2B activator-1 Related Antibodies

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Description

eIF2B activator-1 (Compound 7a) is a eIF2B activator with a pEC50 value of 7.3. eIF2B activator-1 exhibits significant hERG inhibitory activity, with a pIC50 value of 5.7. eIF2B activator-1 can be used in research related to Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

IC50 & Target[1]

eIF2

7.3 (pEC50)

Molecular Weight

481.33

Formula

C22H22Cl2N2O6
CAS No.
SMILES

O=C(COC1=CC=C(Cl)C=C1)N[C@@H](CO[C@]([C@@H](CO2)NC(COC3=CC=C(Cl)C=C3)=O)4[H])[C@]42[H]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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eIF2B activator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF2B activator-13118633-46-5Eukaryotic Initiation Factor (eIF)Potassium ChannelKcsAprotein synthesishuman ether-a-go-go-related genehERG potassium channelcardiac repolarizationparkinson'samyotrophic lateral sclerosishuntington'sSH-SY5Y human neuroblastoma cellseIF2B-mediated signalingeukaryotic initiation factor 2 betaInhibitorinhibitorinhibit

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