hCAIX/XII-IN-8
hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II.
For research use only. We do not sell to patients.
- CAS No.: 59994-64-8
- Formula: C16H13Cl2N5O3S
- Molecular Weight:426.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA XII 6.7 nM (Ki) |
hCA IX 8.5 nM (Ki) |
hCA II 72.0 nM (Ki) |
hCA I 5269 nM (Ki) |
Chemical Information
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CAS No. 59994-64-8
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Molecular Weight 426.28
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Formula C16H13Cl2N5O3S
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SMILES
O=C(N(N=C/1C)C2=CC=C(Cl)C=C2Cl)C1=N\NC(C=C3)=CC=C3S(=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX/XII-IN-8 Related Classifications
HY-156181 Related Classifications
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