PF-05139962
PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity.
For research use only. We do not sell to patients.
- CAS No.: 1393712-18-9
- Formula: C21H27N5O4S
- Molecular Weight:445.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mTOR 5 nM (Ki) |
Chemical Information
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CAS No. 1393712-18-9
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Molecular Weight 445.54
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Formula C21H27N5O4S
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SMILES
O=C(NCC)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(CS4(=O)=O)C(CC4)=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-05139962 Related Classifications
HY-108338 Related Classifications
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