2. PI3K/Akt/mTOR
  3. mTOR
  4. PF-05139962

PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity.

For research use only. We do not sell to patients.

PF-05139962

PF-05139962 Chemical Structure

CAS No. : 1393712-18-9

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PF-05139962 Related Antibodies

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Description

PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity[1].

IC50 & Target[1]

mTOR

5 nM (Ki)

Molecular Weight

445.54

Formula

C21H27N5O4S
CAS No.
SMILES

O=C(NCC)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(CS4(=O)=O)C(CC4)=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-05139962 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-051399621393712-18-9PF05139962PF 05139962mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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PF-05139962
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