1393712-18-9
1393712-18-9
Chemical Structure
PF-05139962
- CAS No.: 1393712-18-9
- Formula:C21H27N5O4S
- Molecular Weight:445.54
IUPAC Name: (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,6-dioxido-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea
InChIKey: NLFYWTSGSCFECR-AWEZNQCLSA-N
SMILES: O=C(NCC)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(CS4(=O)=O)C(CC4)=N2)C=C1
Biological Activity: PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity[1].
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PF-05139962 | PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity. | |||||||||||||||||||||
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References
Keywords
