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Cat. No.: HY-158313

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PROTAC EGFR degrader 13

PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC₅₀ of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC₅₀ of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer.
(Pink: Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker (HY-W262798)).

For research use only. We do not sell to patients.

CAS No.: 2861227-35-0
Formula: C₄₉H₅₅BrN₁₁O₆P
Molecular Weight:1004.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC EGFR degrader 13 Chemical Structure

CAS No.: 2861227-35-0

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC₅₀ of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC₅₀ of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer^[1]. (Pink: Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker (HY-W262798)).

All EGFR Isoforms :

All PROTACs Isoforms :

Chemical Information

CAS No. 2861227-35-0
Molecular Weight 1004.91
Formula C₄₉H₅₅BrN₁₁O₆P
SMILES

O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Zhang, et al. Phosphonyl derivative, and composition and pharmaceutical application thereof. WO2022228547A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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PROTAC EGFR degrader 13

All EGFR Isoforms

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC EGFR degrader 13 Related Classifications

HY-158313 Related Classifications