2861227-35-0
Chemical Structure
PROTAC EGFR degrader 13
- CAS No.: 2861227-35-0
- Formula:C49H55BrN11O6P
- Molecular Weight:1004.91
InChIKey: VKKMJKSVJPZRKD-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Biological Activity: PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer[1].
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PROTAC EGFR degrader 13 | PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer. | |||||||||||||||||||||
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Keywords
