1. MAPK/ERK Pathway
    Apoptosis
  2. MAP3K
    Apoptosis
  3. TC ASK 10

TC ASK 10 

Cat. No.: HY-103258 Purity: 99.84%
Handling Instructions

TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM).

For research use only. We do not sell to patients.

TC ASK 10 Chemical Structure

TC ASK 10 Chemical Structure

CAS No. : 1005775-56-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 333 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1060 In-stock
Estimated Time of Arrival: December 31
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Description

TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM)[1].

IC50 & Target[1]

ASK1

14 nM (IC50)

In Vitro

TC ASK 10 (Compound 10; 0-10 μM; 1 hour; INS-1 cells) treatment inhibits streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 is also inhibited in a dosedependent manner[1].

Western Blot Analysis[1]

Cell Line: INS-1 cells
Concentration: 0 μM, 0.3 μM, 1 μM, 3 μM, 10 μM
Incubation Time: 1 hour
Result: Was found to inhibit streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 was also inhibited in a dosedependent manner.
In Vivo

Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10•HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10[1].

Molecular Weight

432.35

Formula

C₂₁H₂₃Cl₂N₅O

CAS No.

1005775-56-3

SMILES

O=C(NC1=CN2C=C(N3C=CN=C3)C=CC2=N1)C4=CC=C(C(C)(C)C)C=C4.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

TC ASK 10TC ASK10TC ASK-10MAP3KApoptosisMAP kinase kinase kinase, MEKK, MAPKKKPhosphorylationp38JNKoralbioavailabilityASK1pharmacokineticselectiveInhibitorinhibitorinhibit

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TC ASK 10
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HY-103258
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