1005775-56-3
Chemical Structure
TC ASK 10
- CAS No.: 1005775-56-3
- Formula:C21H23Cl2N5O
- Molecular Weight:432.35
IUPAC Name: N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride
InChIKey: IKKLFEDUYFZNBO-UHFFFAOYSA-N
SMILES: O=C(NC1=CN2C=C(N3C=CN=C3)C=CC2=N1)C4=CC=C(C(C)(C)C)C=C4.[H]Cl.[H]Cl
Biological Activity: TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TC ASK 10 | 99.52% | TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
TC ASK 10 (Standard) | ≥98% | TC ASK 10 (Standard) is the analytical standard of TC ASK 10 (HY-103258). This product is intended for research and analytical applications. TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.68
HY-151412T-271 -
Similarity Score 0.64
HY-113831CLK1/2-IN-3 -
Similarity Score 0.59
HY-113670CLK1/2-IN-2 -
Similarity Score 0.59
HY-113825CLK1/2-IN-1 -
Similarity Score 0.58
HY-115470CLK-IN-T3 -
Similarity Score 0.54
HY-101443ISCK03 -
Similarity Score 0.53
HY-130676CLK-IN-T3N -
Similarity Score 0.51
HY-18728STF-31 -
Similarity Score 0.51
HY-W456445Bis(4-(1H-imidazol-1-yl)phenyl)methanone -
Explore the MedChemAI to find more analogs