1. Membrane Transporter/Ion Channel
    Autophagy
  2. GLUT
    Autophagy
  3. STF-31

STF-31 

Cat. No.: HY-18728 Purity: 96.62%
Handling Instructions

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1μM[1][2].

For research use only. We do not sell to patients.

STF-31 Chemical Structure

STF-31 Chemical Structure

CAS No. : 724741-75-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 528 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1μM[1][2].

IC50 & Target[2]

GLUT1

1 μM (IC50)

In Vitro

STF-31 (0.01-10 μM; 10 days) is specifically toxic to RCC4 cells, whereas RCC4/VHL cells are relatively unaffected. RCC4/VHL cells treated with STF-31 (5 μM; 10 days) largely recovery, whereas RCC4 cells under the same conditions does not[1].
STF-31 (1.25-5 μM; 3 days) does not induce autophagy, apoptosis, or DNA damage. STF-31 causes a necrotic cell death[1].

Cell Viability Assay[1]

Cell Line: Wild-type RCC4 cells (RCC4/VHL) and RCC4 cells without VHL
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 10 days
Result: Reduced viability of RCC4 cells without VHL in a concentration-dependent manner when compared to their wild-type counterparts.
In Vivo

Soluble analog of STF-31 (11.6 mg/kg; i.p.) treatment delays tumor growth in mice with VHL-deficient RCC tumor xenografts[1].
STF-31 (10 mg/kg; i.p.; twice daily for 2 days, followed by once daily for another 3 days) does not affect normal mice body weight, behavior, and ERG responses. STF-31 reduces light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration[3].

Animal Model: Twelve-week old C57BL/6J and CX3CR1gfp/+ mice[3]
Dosage: 10 mg/kg
Administration: I.p. injections; twice daily for 2 days, followed by once daily for another 3 days
Result: Improved photoreceptor survival and reduced microglial activation of CX3CR1gfp/+ mice, and not induced any C57BL/6J mice retinal cell death.
Molecular Weight

423.53

Formula

C₂₃H₂₅N₃O₃S

CAS No.

724741-75-7

SMILES

O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (80.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3611 mL 11.8055 mL 23.6111 mL
5 mM 0.4722 mL 2.3611 mL 4.7222 mL
10 mM 0.2361 mL 1.1806 mL 2.3611 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.90 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

STF-31STF31STF 31GLUTAutophagyGlucose transporterinhibitorglucoseGLUT1RCC4/VHLRCC4VHLInhibitorinhibit

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Product Name:
STF-31
Cat. No.:
HY-18728
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