724741-75-7
724741-75-7
Chemical Structure
STF-31
- CAS No.: 724741-75-7
- Formula:C23H25N3O3S
- Molecular Weight:423.53
IUPAC Name: 4-(((4-(tert-butyl)phenyl)sulfonamido)methyl)-N-(pyridin-3-yl)benzamide
InChIKey: NGQPRVWTFNBUHA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
Biological Activity: STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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STF-31 | 99.79% | STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-180866GRIN2A modulator-1 -
Similarity Score 0.62
HY-135843TH-263 -
Similarity Score 0.61
HY-19977YU238259 -
Similarity Score 0.61
HY-112543S119-8 -
Similarity Score 0.60
HY-157555NLRP3-IN-29 -
Similarity Score 0.59
HY-13457TCN 201 -
Similarity Score 0.59
HY-136217PU 23 -
Similarity Score 0.59
HY-148309Anti-Influenza agent 4 -
Similarity Score 0.59
HY-155949Bt354 -
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References
- [1]. Chan DA, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 3;3(94):94ra70. [Content Brief]
- [2]. Dedda CD, et al. Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses. International Journal of Molecular Sciences. 2019 Oct 8; 20(19):4962. [Content Brief]
