PU 23
Based on 1 Customer Validation
PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 817635-93-1
- Formula: C21H19N3O3S2
- Molecular Weight:425.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Membrane Transporter/Ion Channel Compound Library
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Anti-Cancer Compound Library
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Biological Activity
6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively[1].
Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 817635-93-1
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Appearance Solid
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Molecular Weight 425.52
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Formula C21H19N3O3S2
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Color Off-white to yellow
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SMILES
O=C(NC(NC1=CC=C(S(=O)(NCC2=CC=CC=C2)=O)C=C1)=S)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (293.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3501 mL | 11.7503 mL | 23.5007 mL | 58.7516 mL |
| 5 mM | 0.4700 mL | 2.3501 mL | 4.7001 mL | 11.7503 mL | |
| 10 mM | 0.2350 mL | 1.1750 mL | 2.3501 mL | 5.8752 mL | |
| 15 mM | 0.1567 mL | 0.7834 mL | 1.5667 mL | 3.9168 mL | |
| 20 mM | 0.1175 mL | 0.5875 mL | 1.1750 mL | 2.9376 mL | |
| 25 mM | 0.0940 mL | 0.4700 mL | 0.9400 mL | 2.3501 mL | |
| 30 mM | 0.0783 mL | 0.3917 mL | 0.7834 mL | 1.9584 mL | |
| 40 mM | 0.0588 mL | 0.2938 mL | 0.5875 mL | 1.4688 mL | |
| 50 mM | 0.0470 mL | 0.2350 mL | 0.4700 mL | 1.1750 mL | |
| 60 mM | 0.0392 mL | 0.1958 mL | 0.3917 mL | 0.9792 mL | |
| 80 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7344 mL | |
| 100 mM | 0.0235 mL | 0.1175 mL | 0.2350 mL | 0.5875 mL |
PU 23 Related Classifications
HY-136217 Related Classifications
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