HDAC6-IN-18
HDAC6-IN-18 (Compound 4) is a first irreversible HDAC6 isoform selective inhibitor with potent anti-multiple myeloma activity. HDAC6-IN-18 has HDAC6 inhibitory activity in RPMI8266, U266 and MM.1S cells with IC50 values of 0.17, 0.7 and 0.42 μM, respectively.
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- No. CAS: 2998942-88-2
- Fòrmula: C16H13N3O7S
- Peso molecular:391.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L02 | IC50 |
8.2 μM
Compound: 4
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Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
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[PMID: 37463038] |
| MM1.S | IC50 |
0.42 μM
Compound: 4
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Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
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[PMID: 37463038] |
| RPMI-8226 | IC50 |
0.17 μM
Compound: 4
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Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
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[PMID: 37463038] |
| U-266 | IC50 |
0.7 μM
Compound: 4
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Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
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[PMID: 37463038] |
Chemical Information
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No. CAS 2998942-88-2
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Peso molecular 391.36
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Fòrmula C16H13N3O7S
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SMILES
[O-][N+]1=C(C(OCC2=CC=C(C=C2)C(NO)=O)=NO1)S(=O)(C3=CC=CC=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-18 Related Classifications
HY-155671 Related Classifications
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