GTx-134
GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC50 values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators). GTx-134 can be used in high-risk myeloma research.
For research use only. We do not sell to patients.
- CAS No.: 1008448-19-8
- Formula: C33H40N6O6S
- Molecular Weight:648.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1008448-19-8
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Molecular Weight 648.77
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Formula C33H40N6O6S
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SMILES
CC(C=C(C=C1)C)=C1OC[C@H](O)CNC2=C(C(NC=C2)=O)C3=NC(C=C4C(C(N(C5CCN(CC5)CCS(C)(=O)=O)C4)=O)=C6)=C6N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GTx-134 Related Classifications
HY-13312A Related Classifications
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