1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

HS-10296 hydrochloride 

Cat. No.: HY-112823B Purity: 98.05%
Handling Instructions

HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

For research use only. We do not sell to patients.

HS-10296 hydrochloride Chemical Structure

HS-10296 hydrochloride Chemical Structure

CAS No. : 2134096-03-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 680 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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  • References

Description

HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

IC50 & Target

EGFR[1].

In Vitro

HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (148.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7790 mL 8.8951 mL 17.7901 mL
5 mM 0.3558 mL 1.7790 mL 3.5580 mL
10 mM 0.1779 mL 0.8895 mL 1.7790 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.70 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.70 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.70 mM); Clear solution

References
Molecular Weight

562.11

Formula

C₃₀H₃₆ClN₇O₂

CAS No.

2134096-03-8

SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
HS-10296 hydrochloride
Cat. No.:
HY-112823B
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HS-10296 hydrochloride

Cat. No.: HY-112823B