2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Almonertinib mesylate

Almonertinib mesylate  (Synonyms: HS-10296 mesylate)

Cat. No.: HY-112823A Purity: 99.85%
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Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer.

For research use only. We do not sell to patients.

Almonertinib mesylate Chemical Structure

Almonertinib mesylate Chemical Structure

CAS No. : 2134096-06-1

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Based on 3 publication(s) in Google Scholar

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Almonertinib mesylate Related Antibodies

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Description

Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer[1][2].

In Vitro

HS-10296 mesylate is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[2]. Additionaly, HS-10296 mesylate could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Almonertinib mesylate Related Antibodies
Clinical Trial
Molecular Weight

621.75

Formula

C31H39N7O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (50.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6084 mL 8.0418 mL 16.0836 mL
5 mM 0.3217 mL 1.6084 mL 3.2167 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6084 mL 8.0418 mL 16.0836 mL 40.2091 mL
5 mM 0.3217 mL 1.6084 mL 3.2167 mL 8.0418 mL
10 mM 0.1608 mL 0.8042 mL 1.6084 mL 4.0209 mL
15 mM 0.1072 mL 0.5361 mL 1.0722 mL 2.6806 mL
20 mM 0.0804 mL 0.4021 mL 0.8042 mL 2.0105 mL
25 mM 0.0643 mL 0.3217 mL 0.6433 mL 1.6084 mL
30 mM 0.0536 mL 0.2681 mL 0.5361 mL 1.3403 mL
40 mM 0.0402 mL 0.2010 mL 0.4021 mL 1.0052 mL
50 mM 0.0322 mL 0.1608 mL 0.3217 mL 0.8042 mL
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Almonertinib mesylate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Almonertinib2134096-06-1HS-10296HS10296HS 10296EGFREpidermal growth factor receptorErbB-1HER1orally availableirreversiblethird-generationEGFR tyrosine kinase inhibitornon-small cell lung cancerInhibitorinhibitorinhibit

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