1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Almonertinib mesylate

Almonertinib mesylate (Synonyms: HS-10296 mesylate)

Cat. No.: HY-112823A Purity: 99.85%
Handling Instructions

Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer.

For research use only. We do not sell to patients.

Almonertinib mesylate Chemical Structure

Almonertinib mesylate Chemical Structure

CAS No. : 2134096-06-1

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Based on 2 publication(s) in Google Scholar

Other Forms of Almonertinib mesylate:

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2 Publications Citing Use of MCE Almonertinib mesylate

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Description

Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer[1][2].

In Vitro

HS-10296 mesylate is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[2]. Additionaly, HS-10296 mesylate could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

621.75

Formula

C31H39N7O5S

CAS No.
SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (50.26 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6084 mL 8.0418 mL 16.0836 mL
5 mM 0.3217 mL 1.6084 mL 3.2167 mL
10 mM 0.1608 mL 0.8042 mL 1.6084 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Almonertinib mesylate
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HY-112823A
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