1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. HS-10296

HS-10296 

Cat. No.: HY-112823
Handling Instructions

HS-10296, an orally available and third-generation EGFR-activating mutations and T790M-resistant mutation inhibitor, shows limited activity against wild-type EGFR.

For research use only. We do not sell to patients.

HS-10296 Chemical Structure

HS-10296 Chemical Structure

CAS No. : 1899921-05-1

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Description

HS-10296, an orally available and third-generation EGFR-activating mutations and T790M-resistant mutation inhibitor, shows limited activity against wild-type EGFR[1][2].

IC50 & Target[1]

EGFRT790M

 

In Vitro

HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].

Molecular Weight

525.64

Formula

C₃₀H₃₅N₇O₂

CAS No.

1899921-05-1

SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (158.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9024 mL 9.5122 mL 19.0244 mL
5 mM 0.3805 mL 1.9024 mL 3.8049 mL
10 mM 0.1902 mL 0.9512 mL 1.9024 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (11.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (11.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

HS-10296HS10296HS 10296EGFREpidermal growth factor receptorErbB-1HER1oralantineoplasticmutationsG719Xdel19L858RL861Qnon-smallcelllungcancerNSCLCInhibitorinhibitorinhibit

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Product name:
HS-10296
Cat. No.:
HY-112823
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