2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Almonertinib

Almonertinib  (Synonyms: HS-10296)

Cat. No.: HY-112823 Purity: 99.98%
COA Handling Instructions

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

For research use only. We do not sell to patients.

Almonertinib Chemical Structure

Almonertinib Chemical Structure

CAS No. : 1899921-05-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 318 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 318 In-stock
Solid
5 mg USD 275 In-stock
10 mg USD 440 In-stock
25 mg USD 825 In-stock
50 mg USD 1155 In-stock
100 mg USD 1595 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 3 publication(s) in Google Scholar

Other Forms of Almonertinib:

Almonertinib Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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  • Customer Review

Description

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer[1][2].

IC50 & Target[1]

EGFRT790M

0.37 nM (IC50)

EGFRL858R/T790M

0.29 nM (IC50)

EGFRdel19 T790M

0.21 nM (IC50)

In Vitro

HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[2]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Almonertinib Related Antibodies
Clinical Trial
Molecular Weight

525.64

Appearance

Solid

Formula

C30H35N7O2
CAS No.
SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (158.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9024 mL 9.5122 mL 19.0244 mL
5 mM 0.3805 mL 1.9024 mL 3.8049 mL
10 mM 0.1902 mL 0.9512 mL 1.9024 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (11.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (11.89 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Almonertinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Almonertinib1899921-05-1HS-10296HS10296HS 10296EGFREpidermal growth factor receptorErbB-1HER1oralantineoplasticmutationsG719Xdel19L858RL861Qnon-smallcelllungcancerNSCLCInhibitorinhibitorinhibit

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