HDAC6 ligand-7
HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging.
For research use only. We do not sell to patients.
- Formula: C17H15FN4O2
- Molecular Weight:326.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
hHDAC6 2.7 nM (IC50) |
hHDAC1 1300 nM (IC50) |
hHDAC4 >10000 nM (IC50) |
hHDAC7 4400 nM (IC50) |
hHDAC8 640 nM (IC50) |
Chemical Information
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Molecular Weight 326.33
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Formula C17H15FN4O2
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SMILES
O=C(NO)C1=CC=C(CN2N=C(C)C=C2C3=NC(F)=CC=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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