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Nepafenac (Standard)

(Synonyms: AHR 9434 (Standard); AL 6515 (Standard))

Nepafenac (AHR 9434; AL 6515) (Standard) is the analytical standard of Nepafenac (HY-17357). This product is intended for research and analytical applications. Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.

For research use only. We do not sell to patients.

  • Purity : 98%
  • CAS No.: 78281-72-8
  • Formula: C15H14N2O2
  • Molecular Weight:254.28
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Nepafenac (Standard) Chemical Structure
    Nepafenac (Standard) Chemical Structure
CAS No.: 78281-72-8
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Nepafenac (Standard) Chemical Structure
    Nepafenac (Standard) Chemical Structure
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  • Nepafenac (Standard)