1. Immunology/Inflammation
  2. COX
  3. Nepafenac

Nepafenac (Synonyms: AHR 9434; AL 6515)

Cat. No.: HY-17357 Purity: 95.14%
Handling Instructions

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.

For research use only. We do not sell to patients.

Nepafenac Chemical Structure

Nepafenac Chemical Structure

CAS No. : 78281-72-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac. IC50 value: Target: COX-2 Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

IC50 & Target

COX-1

64.3 μM (IC50)

COX-2

 

Clinical Trial
Molecular Weight

254.28

Formula

C₁₅H₁₄N₂O₂

CAS No.

78281-72-8

SMILES

O=C(N)CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (125.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NepafenacAHR 9434AL 6515AHR9434AHR-9434AL6515AL-6515COXCyclooxygenaseInhibitorinhibitorinhibit

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Product name:
Nepafenac
Cat. No.:
HY-17357
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