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Cat. No.: HY-124618

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FGI-106

Name: FGI-106
Brand: MedChemExpress
SKU: HY-124618
Availability: PreOrder

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC₅₀s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC₅₀s of 200 nM and 150 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 501081-38-5
Formula: C₂₈H₃₈N₆
Molecular Weight:458.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

FGI-106 Chemical Structure

CAS No.: 501081-38-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

HIV-1

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	EC₅₀	0.4 μM Compound: 87	Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry Antiviral activity against Dengue virus 1 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry	[PMID: 26771861]
Vero C1008	EC₅₀	0.4 μM Compound: 87	Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry Antiviral activity against Dengue virus 2 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry	[PMID: 26771861]
Vero C1008	EC₅₀	0.4 μM Compound: 87	Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry Antiviral activity against Dengue virus 3 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry	[PMID: 26771861]
Vero C1008	EC₅₀	0.4 μM Compound: 87	Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry Antiviral activity against Dengue virus 4 infected in african green monkey Vero E6 cells assessed as inhibition of viral yield after 72 hrs by flow cytometry	[PMID: 26771861]

In Vitro

Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC₉₀ for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM^[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)^[1]
Dosage:

0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
Administration:

Intraperitoneal injection; treatments on days 2 and 5
Result:

Decreased mortality from Zaire EBOV in a dose-dependent manner.

Chemical Information

CAS No. 501081-38-5
Molecular Weight 458.64
Formula C₂₈H₃₈N₆
SMILES

CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aman MJ, et al. Development of a broad-spectrum antiviral with activity against Ebola virus. Antiviral Res. 2009 Sep;83(3):245-51. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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FGI-106

Publications Citing Use of MedChemExpress (MCE) FGI-106

All HIV Isoforms