1. Anti-infection
  2. Influenza Virus
    HCV
    HIV
  3. FGI-106 tetrahydrochloride

FGI-106 tetrahydrochloride 

Cat. No.: HY-124618A
Handling Instructions

FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.

For research use only. We do not sell to patients.

FGI-106 tetrahydrochloride Chemical Structure

FGI-106 tetrahydrochloride Chemical Structure

CAS No. : 1149348-10-6

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Description

FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively[1].

IC50 & Target

EC50: 100 nM (Ebola virus), 800 nM (Rift Valley virus), 400-900 nM (Dengue Fever virus), 200 nM (HCV) and 150 nM (HIV-1)[1]

In Vitro

Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses[1].

In Vivo

FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner[1].

Animal Model: Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)[1]
Dosage: 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
Administration: Intraperitoneal injection; treatments on days 2 and 5
Result: Decreased mortality from Zaire EBOV in a dose-dependent manner.
Molecular Weight

604.49

Formula

C₂₈H₄₂Cl₄N₆

CAS No.

1149348-10-6

SMILES

CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1.Cl.Cl.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FGI-106 tetrahydrochlorideInfluenza VirusHCVHIVHepatitis C virusHuman immunodeficiency virusEBOVbroad-spectrumantiviralhemorrhagicfeverpathogensEbolalethalHIV-1replicationtetrahydrochlorideInhibitorinhibitorinhibit

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FGI-106 tetrahydrochloride
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HY-124618A
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