HIV-1 inhibitor-15
HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability.
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- CAS No.: 2757182-99-1
- Formule: C24H20N6
- Masse moléculaire:392.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HIV-1 (WT) 1.7 nM (EC50) |
HIV-1 (L100I) 4 nM (EC50) |
HIV-1 (K103N) 2 nM (EC50) |
HIV-1 (Y181C) 6 nM (EC50) |
HIV-1 (E138K) 9 nM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MT4 | CC50 |
6 μM
Compound: 9d
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
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[PMID: 35073089] |
Chemical Information
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CAS No. 2757182-99-1
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Masse moléculaire 392.46
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Formule C24H20N6
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SMILES
N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(C4=CC=NC=C4)C=C3C)=N2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-15 Related Classifications
HY-144122 Related Classifications
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