MAO-B-IN-48
MAO-B-IN-48 is a selective MAO-B inhibitor (IC50 = 0.09 μM, Ki = 0.02 μM). MAO-B-IN-48 exhibits inhibitory activity against hBChE (IC50 = 1.10 μM, Ki = 0.43 μM) and AChE (IC50 = 0.56 μM, Ki = 0.14 μM). MAO-B-IN-48 suppresses self-induced aggregation of toxic β-amyloid peptides and exerts antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. MAO-B-IN-48 can be used for the study of Alzheimer's disease (AD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C21H22N2OS
- Molecular Weight:350.48
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
MAO-B 0.09 μM (IC50) |
MAO-B 0.02 μM (Ki) |
MAO-A 30.55 μM (IC50) |
MAO-A 8.33 μM (Ki) |
AChE 0.56 μM (IC50) |
AChE 0.14 μM (Ki) |
hBCHE 1.10 μM (IC50) |
hBCHE 0.43 μM (Ki) |
In Vitro
MAO-B-IN-48 (Compound 1d-R) inhibits self-induced aggregation of Aβ1-40 (IC50 = 31.42 μM) and Aβ1-42 (IC50 = 21.32 μM) in vitro[1].
MAO-B-IN-48 shows DPPH radical scavenging activity (IC50 = 3.40 mM), antioxidant activity in the CUPRAC assay (IC50 = 33.40 μM) and superoxide anion scavenging capacity (IC50 = 28.21 μM)[1].
MAO-B-IN-48 (1-25 μM) does not exhibit cytotoxic effects on HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:40mg/kg of AlCl3 was administered intraperitoneally to male Balb/c mice for 30 days[1]
-
Dosage:20 mg/kg
-
Administration:i.g. for 1 week
-
Result:Ameliorated the cognitive impairment induced by AlCl3 in mice.
Chemical Information
-
Molecular Weight 350.48
-
Formel C21H22N2OS
-
SMILES
C[C@H](C1=CC=CC2=C1C=CC=C2)NC(OC3=CC(N(C)C)=CC=C3)=S
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Teke Tuncel S, et al. Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-β-amyloid (Aβ) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:117986. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MAO-B-IN-48 Related Classifications
HY-175523 Related Classifications
Powered by Bioz