1. Anti-infection
  2. HIV
  3. NBD-556

NBD-556 

Cat. No.: HY-76648 Purity: 99.58%
Handling Instructions

NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.

For research use only. We do not sell to patients.

NBD-556 Chemical Structure

NBD-556 Chemical Structure

CAS No. : 333353-44-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2].

In Vitro

NBD-556 (1-100 μM) inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion[1].
NBD-556 inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains, with IC50s of 6.5, 15.9, and 5.3 µM, respectively[1].
NBD-556 (1-100 μM) inhibits the CD4-dependent virus in a dose-dependent manner with an IC50 of 22.6 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

337.84

Formula

C₁₇H₂₄ClN₃O₂

CAS No.
SMILES

O=C(C(NC1CC(C)(NC(C)(C1)C)C)=O)NC2=CC=C(C=C2)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (98.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9600 mL 14.7999 mL 29.5998 mL
5 mM 0.5920 mL 2.9600 mL 5.9200 mL
10 mM 0.2960 mL 1.4800 mL 2.9600 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NBD-556NBD556NBD 556HIVHuman immunodeficiency virusCD4mimeticHIV-1gp120fusionvirus-cellInhibitorinhibitorinhibit

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Product Name:
NBD-556
Cat. No.:
HY-76648
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