333353-44-9
333353-44-9
Chemical Structure
NBD-556
- CAS No.: 333353-44-9
- Formula:C17H24ClN3O2
- Molecular Weight:337.84
IUPAC Name: N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide
InChIKey: ZKXLQCIOURANAD-UHFFFAOYSA-N
SMILES: O=C(C(NC1CC(C)(NC(C)(C1)C)C)=O)NC2=CC=C(C=C2)Cl
Biological Activity: NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NBD-556 | 99.75% | NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels. | ||||||||||||||||||||
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References
- [1]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339(2):213-25. [Content Brief]
- [2]. Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45(36):10973-10980. [Content Brief]
