P22D
P22D is a BCR-ABL PROTAC degrader based on Dasatinib (HY-10181), with a DC50 value of approximately 10 nM for the wild-type BCR-ABL protein. P22D cannot degrade the BCR-ABL T315I mutant. P22D has inhibitory activity against K562 cells (wild type), but is ineffective against BaF3-BCR-ABL (T315I) cells. P22D can be used for research on chronic myeloid leukemia and acute lymphocytic leukemia.
(Pink: Bcr-Abl ligand (HY-107447); Blue: Cereblon ligand (HY-14658); Black: linker (HY-180980)).
For research use only. We do not sell to patients.
- CAS No.: 2635386-51-3
- Formula: C49H58ClN13O10S
- Molecular Weight:1056.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Bcr-AblWT 10 nM (DC50) |
Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | EC50 |
10 μM
Compound: 10; P22D
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Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay
Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay
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[PMID: 32657579] |
Chemical Information
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CAS No. 2635386-51-3
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Molecular Weight 1056.58
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Formula C49H58ClN13O10S
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SMILES
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CC3)C(CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)=O)=C2)S1)NC8=C(C)C=CC=C8Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P22D Related Classifications
HY-180979 Related Classifications
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