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Cat. No.: HY-144664

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MtTMPK-IN-2

MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC₅₀ value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC₅₀ = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis.

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CAS No.: 2799607-71-7
화학식: C₂₃H₂₄ClN₃O₃
분자량:425.91

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MtTMPK-IN-2 Chemical Structure

CAS No.: 2799607-71-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 1.1 μM (MtTMPK)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	IC₅₀	21 μM Compound: 16	Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis	[PMID: 34450493]

Chemical Information

CAS No. 2799607-71-7
분자량 425.91
화학식 C₂₃H₂₄ClN₃O₃
SMILES

CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC=CC(Cl)=C4)=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song L, et al. Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. Eur J Med Chem. 2021;225:113784. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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