MtTMPK-IN-2
MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 2799607-71-7
- Formula: C23H24ClN3O3
- Molecular Weight:425.91
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 1.1 μM (MtTMPK)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
21 μM
Compound: 16
|
Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis
Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis
|
[PMID: 34450493] |
Chemical Information
-
CAS No. 2799607-71-7
-
Molecular Weight 425.91
-
Formula C23H24ClN3O3
-
SMILES
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC=CC(Cl)=C4)=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MtTMPK-IN-2 Related Classifications
HY-144664 Related Classifications
Powered by Bioz