PD-L1-IN-4
PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2597056-86-3
- Formule: C38H40ClFN4O8
- Masse moléculaire:735.20
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
In Vitro
In Vivo
Pharmacokinetic Analysis in SD Rat Model[1]
| Route | Dose (mg/kg) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-t (ng·h/mL) |
| p.o. | 50 | 5.3 | 0.1 | 45.6 | 82.1 |