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Cat. No.: HY-157318

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PB17-026-01

PB17-026-01 is a potent SHP2 allosteric inhibitor and shows the highest inhibitory activity with an IC₅₀ value of 38.9?nM. PB17-026-01 can be used for the research of tumor.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₅Cl₂N₅O₂
Molecular Weight:462.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PB17-026-01 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PB17-026-01 is a potent SHP2 allosteric inhibitor and shows the highest inhibitory activity with an IC₅₀ value of 38.9?nM. PB17-026-01 can be used for the research of tumor^[1].

IC₅₀ & Target

IC50: 38.9?nM (SHP2)^[1].

Chemical Information

Molecular Weight 462.37
Formula C₂₂H₂₅Cl₂N₅O₂
SMILES

O=C1N(C)C(N(CC2)CCC32[C@@H](N)[C@@H](C)OC3)=NN4C1=C(C5=CC=CC(Cl)=C5Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo Y, et al. Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one. J Enzyme Inhib Med Chem. 2023 Dec;38(1):398-404. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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