Necroptosis-IN-4
Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/2 and PDGFR-α.
For research use only. We do not sell to patients.
- Formula: C26H23F3N6O3
- Molecular Weight:524.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Necroptosis-IN-4 (compound 33) maintains potent antinecroptotic activity for both human and murine cells (human I2.1cells: IC50 < 0.2 nM, Hepa1-6 cells: IC50 < 5 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameter | PO (gavage) |
| Dose (mg/kg) | 3 |
| T1/2 (h) | 1.32 |
| Cmax (ng/mL) | 1243 |
| AUClast (ng·h/mL) | 1145 |
| AUC0-∞ (ng·h/mL) | 1157 |
| MRT0-∞ (h) | 1.21 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 524.49
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Formula C26H23F3N6O3
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SMILES
O=C(CC1=NC(C(F)(F)F)=CC=C1)N2C3=CC=C(OC4=CC(C5=CN(CCO)N=C5)=CN=C4N)C=C3CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Necroptosis-IN-4 Related Classifications
HY-161843 Related Classifications
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