NSD-IN-5
NSD-IN-5 is a nuclear receptor-binding SET domain (NSD) inhibitor with IC50 values of 6 nM and < 1 nM against NSD1 and NSD2, respectively. NSD-IN-5 can be used in research related to multiple myeloma.
For research use only. We do not sell to patients.
- CAS No.: 3034213-62-9
- Formula: C26H28F2N8O2
- Molecular Weight:522.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
NSD2 < 1 nM (IC50) |
NSD1 6 nM (IC50) |
In Vitro
NSD-IN-5 potently inhibits NSD1 histone lysine methyltransferase activity in a cell-free assay with an average IC50 of 6 nM[1].
NSD-IN-5 potently inhibits NSD2 histone lysine methyltransferase activity in a cell-free assay with an average IC50 of <1 nM[1].
NSD-IN-5 inhibits H3K36 dimethylation in KMS11 cells with an average IC50 of 6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3034213-62-9
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Molecular Weight 522.55
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Formula C26H28F2N8O2
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SMILES
FC(C=C(C(F)=C1)OC)=C1C2=NC=C(N3C[C@](N)(CCC3)C(NC)=O)C(CC4=CN=C5N4C=CN=C5N)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)