NSD-IN-5
NSD-IN-5 is a nuclear receptor-binding SET domain (NSD) inhibitor with IC50 values of 6 nM and < 1 nM against NSD1 and NSD2, respectively. NSD-IN-5 can be used in research related to multiple myeloma.
For research use only. We do not sell to patients.
- CAS No.: 3034213-62-9
- Formula: C26H28F2N8O2
- Molecular Weight:522.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
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NSD2 < 1 nM (IC50) |
NSD1 6 nM (IC50) |
NSD-IN-5 potently inhibits NSD1 histone lysine methyltransferase activity in a cell-free assay with an average IC50 of 6 nM[1].
NSD-IN-5 potently inhibits NSD2 histone lysine methyltransferase activity in a cell-free assay with an average IC50 of <1 nM[1].
NSD-IN-5 inhibits H3K36 dimethylation in KMS11 cells with an average IC50 of 6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3034213-62-9
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Molecular Weight 522.55
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Formula C26H28F2N8O2
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SMILES
FC(C=C(C(F)=C1)OC)=C1C2=NC=C(N3C[C@](N)(CCC3)C(NC)=O)C(CC4=CN=C5N4C=CN=C5N)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSD-IN-5 Related Classifications
HY-177400 Related Classifications
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