Metioprim 

Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria^[1][2].

Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL^[1].
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits E. coli with an MIC value of 0.7 μg/mL^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid^[3].

Pharmacokinetic Analysis^[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

306.38

C₁₄H₁₈N₄O₂S

68902-57-8

NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2.  [Content Brief]

  [2]. Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61.  [Content Brief]

  [3]. Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4.  [Content Brief]