1. Metabolic Enzyme/Protease Anti-infection
  2. Dihydrofolate reductase (DHFR) Bacterial
  3. Metioprim

Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria.

For research use only. We do not sell to patients.

Metioprim Chemical Structure

Metioprim Chemical Structure

CAS No. : 68902-57-8

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Description

Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].

In Vitro

Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL[1].
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits E. coli with an MIC value of 0.7 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid[3].

Pharmacokinetic Analysis[1]

Animal Route Dose (mg/kg) C0 (μg/mL) A (μg/mL) α (1/min) t1/2α (min) B (μg/mL) β (1/min) t1/2β (min) VC (1/kg) Vp (1/kg) Vd,ss (1/kg) Clβ (mL/min/kg)
Pigs i.v. 5 3.6 2.1 0.032 25 1.5 0.00415 169 1.45 0.74 2.19 10.0
Goats i.v. 10 12.2 6.4 0.220 4 5.6 0.03138 23 0.85 0.44 1.28 49

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

306.38

Formula

C14H18N4O2S

CAS No.
SMILES

NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Metioprim
Cat. No.:
HY-122289
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