68902-57-8
68902-57-8
Chemical Structure
Metioprim
- CAS No.: 68902-57-8
- Formula:C14H18N4O2S
- Molecular Weight:306.38
IUPAC Name: 5-(3,5-dimethoxy-4-(methylthio)benzyl)pyrimidine-2,4-diamine
InChIKey: HRZQMMXCASMDBP-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1
Biological Activity: Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].
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Metioprim | Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria. | |||||||||||||||||||||
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References
- [1]. Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. [Content Brief]
- [2]. Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61. [Content Brief]
