HIV-1 inhibitor-14
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM.
For research use only. We do not sell to patients.
- CAS No.: 2761172-65-8
- Formula: C29H32N6O4S
- Molecular Weight:560.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 6.17 nM (EC50) |
HIV-1 (L100I) 12.4 nM (EC50) |
HIV-1 (K103N) 6.91 nM (EC50) |
HIV-1 (Y181C) 8.91 nM (EC50) |
HIV-1 (Y188L) 7.66 nM (EC50) |
HIV-1 (F227L+V106A) 5.79 nM (EC50) |
HIV-1 (K103N+Y181C) 27.9 nM (EC50) |
HIV-1 (E138K) 7.66 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
38.8 μM
Compound: 14b
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 35061384] |
Chemical Information
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CAS No. 2761172-65-8
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Molecular Weight 560.67
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Formula C29H32N6O4S
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SMILES
CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C3COCC3=NC(NC4CCN(CC4)C5=CC=C(C=C5)NS(=O)(C)=O)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-14 Related Classifications
HY-144113 Related Classifications
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