2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-14

HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM.

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HIV-1 inhibitor-14 Chemical Structure

HIV-1 inhibitor-14 Chemical Structure

CAS No. : 2761172-65-8

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HIV-1 inhibitor-14 Related Antibodies

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Description

HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM[1].

IC50 & Target[1]

HIV-1 (WT)

6.17 nM (EC50)

HIV-1 (L100I)

12.4 nM (EC50)

HIV-1 (K103N)

6.91 nM (EC50)

HIV-1 (Y181C)

8.91 nM (EC50)

HIV-1 (Y188L)

7.66 nM (EC50)

HIV-1 (F227L+V106A)

5.79 nM (EC50)

HIV-1 (K103N+Y181C)

27.9 nM (EC50)

HIV-1 (E138K)

7.66 nM (EC50)

Molecular Weight

560.67

Formula

C29H32N6O4S
CAS No.
SMILES

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C3COCC3=NC(NC4CCN(CC4)C5=CC=C(C=C5)NS(=O)(C)=O)=N2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-142761172-65-8HIVHuman immunodeficiency virusAnti-HIVAIDSReverse transcriptaseBroad-spectrumHIV-1 resistant strainsInhibitorinhibitorinhibit

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HIV-1 inhibitor-14
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HY-144113
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