2761172-65-8
Chemical Structure
HIV-1 inhibitor-14
- CAS No.: 2761172-65-8
- Formula:C29H32N6O4S
- Molecular Weight:560.67
IUPAC Name: (E)-N-(4-(4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)amino)piperidin-1-yl)phenyl)methanesulfonamide
InChIKey: FXZZYPMLKSEPLC-SNAWJCMRSA-N
SMILES: CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C3COCC3=NC(NC4CCN(CC4)C5=CC=C(C=C5)NS(=O)(C)=O)=N2
Biological Activity: HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM[1].
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HIV-1 inhibitor-14 | HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM. | |||||||||||||||||||||
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Keywords
