JANEX-1 hydrochloride
Based on 4 publication(s) in Google Scholar
JANEX-1 (WHI-P131) hydrochloride is a potent and specific JAK3 inhibitor (Ki=2.3 μM). JANEX-1 hydrochloride shows potent JAK3 inhibitory activity (IC50=78 μM), does not inhibit JAK1 and JAK2.
For research use only. We do not sell to patients.
- CAS No.: 188829-39-2
- Formula: C16H16ClN3O3
- Molecular Weight:333.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) JANEX-1 hydrochloride
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Biological Activity
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JAK3 78 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
51.472 μM
Compound: 5b
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Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
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[PMID: 21185195] |
| HT-29 | IC50 |
92.994 μM
Compound: 5b
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Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
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[PMID: 21185195] |
| Jurkat | IC50 |
3 μM
Compound: 14
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Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.
Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.
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10.1016/S0960-894X(97)00034-6 |
| SK-OV-3 | IC50 |
74.595 μM
Compound: 5b
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Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
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[PMID: 21185195] |
Chemical Information
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CAS No. 188829-39-2
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Molecular Weight 333.77
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Formula C16H16ClN3O3
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SMILES
COC1=CC2=NC=NC(NC3=CC=C(O)C=C3)=C2C=C1OC.[H]Cl
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Synonyms
WHI-P131 hydrochloride; Jak3 inhibitor I hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Science
2017 Dec 1;358(6367):eaan4368. PMID: 29191878 -
Autophagy
2018;14(3):450-464. PMID: 29297752
JANEX-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2018;14(3):450-464. [Abstract]
Autophagy is induced by IL4 in primary B cells. (A) WT asthma-prone mice were pretreated with the JAK3 inhibitor JANEX-1 before atomized OVAL challenge
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Purity & Documentation
References
[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]
[2]. Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 [Content Brief]
[3]. Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. [Content Brief]
[4]. Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JANEX-1 hydrochloride Related Classifications
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