188829-39-2
188829-39-2
Chemical Structure
JANEX-1 hydrochloride
Synonym(s): WHI-P131 hydrochloride; Jak3 inhibitor I hydrochloride
- CAS No.: 188829-39-2
- Formula:C16H16ClN3O3
- Molecular Weight:333.77
IUPAC Name: 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol hydrochloride
InChIKey: HNJNNCPPISFBGR-UHFFFAOYSA-N
SMILES: COC1=CC2=NC=NC(NC3=CC=C(O)C=C3)=C2C=C1OC.[H]Cl
Biological Activity: JANEX-1 (WHI-P131) hydrochloride is a potent and specific JAK3 inhibitor (Ki=2.3 μM). JANEX-1 hydrochloride shows potent JAK3 inhibitory activity (IC50=78 μM), does not inhibit JAK1 and JAK2[1][2][3][4].
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JANEX-1 hydrochloride | JANEX-1 (WHI-P131) hydrochloride is a potent and specific JAK3 inhibitor (Ki=2.3 μM). JANEX-1 hydrochloride shows potent JAK3 inhibitory activity (IC50=78 μM), does not inhibit JAK1 and JAK2. | |||||||||||||||||||||
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References
- [1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]
- [2]. Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 [Content Brief]
- [3]. Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. [Content Brief]
- [4]. Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464. [Content Brief]
